D-P-Methyl sulfone phenyl ethyl serinate
D-p-Methyl-sulfino phenyl ethyl serinate
CAS: 36983-12-7
Molecular Formula: C12H17NO5S
D-P-Methyl sulfone phenyl ethyl serinate - Names and Identifiers
D-P-Methyl sulfone phenyl ethyl serinate - Physico-chemical Properties
| Molecular Formula | C12H17NO5S |
| Molar Mass | 287.33 |
| Density | 1.309 |
| Melting Point | 135-137°C |
| Boling Point | 515.0±50.0 °C(Predicted) |
| Flash Point | 265.233°C |
| Solubility | Chloroform |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White |
| pKa | 10.57±0.45(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.554 |
| Use | Mainly used for the production of thiamphenicol |
D-P-Methyl sulfone phenyl ethyl serinate - Reference
| Reference Show more | 1. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin,An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids,Chemical Engineering Science,Volume 226,2020,115812,ISSN 0009-2509,https://doi.org/10.1016/j.ces.2020.115812. 2. [IF=4.311] Li-Chao Wang et al."An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids."Chem Eng Sci. 2020 Nov;226:115812 |
D-P-Methyl sulfone phenyl ethyl serinate - Reference Information
| application | D-p-sulfone phenylserine ethyl ester is an important raw material for the synthesis of florfenicol. Florfenicol is a new generation of chloramphenicol animal-specific broad-spectrum antibiotics, which has a wide range of uses in clinical medicine and agriculture. In recent years, people's demand for it is increasing year by year. |
| preparation | in a 500ml reaction bottle, 34g of copper sulfate, 250ml of purified water are added, stirred and dissolved, 19g of glycine, 42g of p-methylsulfone benzaldehyde are added, ammonia water is adjusted to pH = 9, water is controlled to react at 50 ℃ for 22 hours, filtration is carried out, the filter cake is dissolved in 300ml of anhydrous ethanol, 40g of concentrated sulfuric acid is added dropwise, reflux is carried out for 2.5 hours, thermal filtration is, cooling crystallization, suction filtration, dissolving the filter cake in water, adjusting the pH = 9 in ammonia water, precipitating the solid, filtering and drying to obtain racemic ester, dissolving the racemic ester in 3 times ethanol, adding L-tartaric acid, refluxing for 2.5 hours, the obtained solid is the product, the mother liquor is racemized and applied, the solid is dried to obtain 20.1g of the product, and the yield is 42.3%. |
Last Update：2024-04-09 20:52:54
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